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  43  Researchers Develop Tomato that Fights Cancer U. S. Depa 2002-08-09 1344
  Bioengineered fruit has high levels of antioxidant lycopene

Tomatoes containing three times more of the cancer-fighting antioxidant lycopene have been developed by researchers from Purdue University and the U.S. Department of Agriculture (USDA). Bioengineered fruit has high levels of antioxidant lycopene

According to a June 17 press release, the scientists were working to develop bioengineered tomatoes for food processing that were of higher quality and would ripen later than known varieties. In the process, they discovered that the new tomatoes also had more of the pigment lycopene than conventional tomatoes. Bioengineered fruit has high levels of antioxidant lycopene

"This is one of the first examples of increasing the nutritional value of food through biotechnology," said Avtar Handa, professor of horticulture at Purdue. Co-discoverer Autar Mattoo, who heads the USDA Vegetable Laboratory, said the increase in lycopene occurred naturally in the genetically modified tomatoes. Bioengineered fruit has high levels of antioxidant lycopene

Lycopene is a pigment that gives tomatoes their characteristic red color and is one of hundreds of carotenoids that color fruits and vegetables, the most familiar being beta-carotene, which is found in carrots. In the body these pigments capture electrically charged oxygen molecules that can damage tissue. Because of this they are called antioxidants. Bioengineered fruit has high levels of antioxidant lycopene

Lycopene has been the focus of much attention since 1995, when a six-year study by Harvard University found that men who ate four to seven servings of foods per week containing tomato sauce or tomatoes were 20 percent less likely to develop prostate cancer. Bioengineered fruit has high levels of antioxidant lycopene

Research has found that lycopene also reduces the amount of oxidized low-density lipoprotein -- the so-called bad cholesterol -- and therefore may reduce the risk of heart disease. Bioengineered fruit has high levels of antioxidant lycopene

Handa said the technique used in the latest research might also be used to increase the amount of other antioxidants in foods. Bioengineered fruit has high levels of antioxidant lycopene

A USDA article on the cancer-fighting tomato can be found at the following Web site: http://www.ars.usda.gov/is/AR/archive/sep00/tomato0900.htm Bioengineered fruit has high levels of antioxidant lycopene

Following is the text of the press release: Bioengineered fruit has high levels of antioxidant lycopene

(begin text) Bioengineered fruit has high levels of antioxidant lycopene

Purdue University
Purdue News
June 17, 2002 Bioengineered fruit has high levels of antioxidant lycopene

Tomato packs more cancer-fighting punch Bioengineered fruit has high levels of antioxidant lycopene

WEST LAFAYETTE, Ind. - Forget the attack of the killer tomato, this is the attack of the healthy tomato: A team of scientists has developed a tomato that contains as much as three and a half times more of the cancer-fighting antioxidant lycopene. Bioengineered fruit has high levels of antioxidant lycopene

It turns out that the antioxidant-rich tomato was a happy accident. Bioengineered fruit has high levels of antioxidant lycopene

Bioengineered fruit has high levels of antioxidant lycopene

Scientists at Purdue University and the U.S. Department of Agriculture's Agricultural Research Service were working to develop tomatoes for food processing that were of higher quality and would ripen later. Bioengineered fruit has high levels of antioxidant lycopene

They accomplished that, but in the process they discovered that the new tomatoes also had significantly more of the antioxidant than conventional tomatoes. Bioengineered fruit has high levels of antioxidant lycopene

"We were quite pleasantly surprised to find the increase in lycopene," says Avtar Handa (pronounced "Honda"), professor of horticulture at Purdue. Bioengineered fruit has high levels of antioxidant lycopene

Although increasing the nutritional value of foods is the goal of so-called second-generation biotechnology products, there have been few success stories. Bioengineered fruit has high levels of antioxidant lycopene

"This is one of the first examples of increasing the nutritional value of food through biotechnology," Handa says. "In fact, it may be the first example of using biotechnology to increase the nutritional value of a fruit." Bioengineered fruit has high levels of antioxidant lycopene

Co-discoverer Autar Mattoo, who heads the USDA Vegetable Laboratory, says the increase in lycopene occurred naturally in the genetically modified tomatoes. "The pattern for the accumulation was the same as in the control tomatoes," he says. "The lycopene levels increased two to 3.5 times compared to the non-engineered tomatoes." Bioengineered fruit has high levels of antioxidant lycopene

The research was announced this week in the June issue of Nature Biotechnology. Bioengineered fruit has high levels of antioxidant lycopene

A separate article on the research in Nature Biotechnology noted, "The findings ... remind us that in the 'rational' and quantitatively driven post-genomic era, serendipity still has a large part to play." Bioengineered fruit has high levels of antioxidant lycopene

A U.S. patent application has been filed on behalf of the joint owners USDA and the Purdue Research Foundation. The Consortium for Plant Biotechnology Research Inc., a USDA funded program, funded the research. Bioengineered fruit has high levels of antioxidant lycopene

Lycopene is a pigment that gives tomatoes their characteristic red color. It is one of hundreds of carotenoids that color fruits and vegetables red, orange or yellow. Of these pigments, the most familiar is the beta-carotene, which is found in carrots. Bioengineered fruit has high levels of antioxidant lycopene

In the body these pigments capture electrically charged oxygen molecules that can damage tissue. Because of this they are called antioxidants. Bioengineered fruit has high levels of antioxidant lycopene

Lycopene has been the focus of much attention since 1995, when a six-year study of nearly 48,000 men by Harvard University found that men who ate at least 10 servings of foods per week containing tomato sauce or tomatoes were 45 percent less likely to develop prostate cancer. The study also found that those who ate four to seven servings per week were 20 percent less likely to develop the cancer. Bioengineered fruit has high levels of antioxidant lycopene

That research was published in the Journal of the National Cancer Institute. Bioengineered fruit has high levels of antioxidant lycopene

Subsequent research has found that lycopene also reduces the amount of oxidized low-density lipoprotein - the so-called bad cholesterol - and therefore may reduce the risk of heart disease. Bioengineered fruit has high levels of antioxidant lycopene

As an antioxidant, lycopene is able to capture twice as many oxygen ions in the body as is beta-carotene. Bioengineered fruit has high levels of antioxidant lycopene

"This characteristic may be responsible for lycopene's ability to mitigate epithelial cancers, such as breast cancer and prostate cancer, and for its ability to mitigate coronary artery disease," Mattoo says. Bioengineered fruit has high levels of antioxidant lycopene

Despite the apparent benefits, it's been difficult to increase the amount of lycopene in the diet, says Randy Woodson, director of Agricultural Research Programs at Purdue. Bioengineered fruit has high levels of antioxidant lycopene

Studies have found that taking purified antioxidants as a dietary supplement doesn't work. In fact, one study found that giving beta-carotene to smokers actually increased their chances of developing cancer. Bioengineered fruit has high levels of antioxidant lycopene

"When you just take lycopene as a drug it doesn't have the same effect," Woodson says. "There is still a lot of biology to understand before we know why phytonutrients in food are so much more effective than if they are given as supplements." Bioengineered fruit has high levels of antioxidant lycopene

Another wrinkle is that when it comes to lycopene in tomatoes, cooked tomato sauces are more effective than raw tomatoes. Bioengineered fruit has high levels of antioxidant lycopene

This may be because cooking breaks the cell walls of the tomato, releasing more of the lycopene. Or it may be that cooking oil allows the lycopene to move more easily into the body. Bioengineered fruit has high levels of antioxidant lycopene

To develop the lycopene-rich tomato, the researchers inserted a gene, derived from yeast, fused to a promoter gene into tomato plants. The promoter gene helps turn on the yeast gene in the tomato. Bioengineered fruit has high levels of antioxidant lycopene

"The promoter gene is like a ZIP code that tells the yeast gene when and where to turn on in tomato," Handa says. "For high-lycopene tomatoes we used a promoter that targeted expression of the introduced gene in fruits only." Bioengineered fruit has high levels of antioxidant lycopene

The yeast gene itself produces an enzyme that affected the production of growth substances in the plants called polyamines, which are known to help prevent cell death. Bioengineered fruit has high levels of antioxidant lycopene

In plant cells, polyamines help build new, beneficial compounds.

Bioengineered fruit has high levels of antioxidant lycopene

"They may stabilize membrane networks that involve longevity of physical structures in the cells called chromoplasts," Mattoo says. "Because lycopene accumulates in chromoplasts in the tomato fruit cells, in this case the polyamines seem to have a positive effect."

The polyamines share a precursor with a plant hormone called ethylene that causes ripening in many fruits.

The researchers thought that because ripening was delayed there must have been a decrease in ethylene, but found the opposite was true.

"That's not how we started out thinking, but that's why we do experiments," Mattoo says. "Now we know the change - i.e., allowing the accumulation of polyamines in the fruit - doesn't necessarily affect ethylene production, but ethylene action. We think the polyamines has changed the ethylene receptors on the cell membranes, but we are looking into that."

Handa says the technique used in this research might also be used to increase the amount of other antioxidants in foods.

"We are excited about this approach, not only because it results in an increase in lycopene in tomato, but because we think this approach could be used to increase the phytonutrient content of other fruits and vegetables," he says.

 

 

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